Microarray analysis of sexually dimorphic gene expression in human minor salivary glands.

ABSTRACT:

Objective

We hypothesized that differential mRNA transcription between the sexes may be linked to the 9:1 female-to-male gender-related relative risk for the development of Sjögren's syndrome (SS), an autoimmune disease that leads to inflammation and dysfunction in the lachrymal and salivary glands.

Subjects and methods

RNA from minor salivary glands was collected from nine healthy volunteers (four men and five women) and analyzed using the Agilent 4 × 44K human microarray platform. Differential expression was confirmed by qRT-PCR.

Results

Comparison of the transcriptome of minor salivary glands from normal male and female volunteers with that of salivary glands and secretory epithelia identified a number of gender, species, and tissue-specific gene expression pattern

SUBMITTER: Michael D 

PROVIDER: S-EPMC4083356 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature