The structural network of Interleukin-10 and its implications in inflammation and cancer.

ABSTRACT:

Background

Inflammation has significant roles in all phases of tumor development, including initiation, progression and metastasis. Interleukin-10 (IL-10) is a well-known immuno-modulatory cytokine with an anti-inflammatory activity. Lack of IL-10 allows induction of pro-inflammatory cytokines and hinders anti-tumor immunity, thereby favoring tumor growth. The IL-10 network is among the most important paths linking cancer and inflammation. The simple node-and-edge network representation is useful, but limited, hampering the understanding of the mechanistic details of signaling pathways. Structural networks complete the missing parts, and provide details. The IL-10 structural network may shed light on the mechanisms through which disease-related mutations work and the pathogenesis o

SUBMITTER: Acuner-Ozbabacan ES 

PROVIDER: S-EPMC4083408 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature