Effect of OPRM1 and stressful life events on symptoms of major depression in African American adolescents.

ABSTRACT:

Background

In a community sample of low-income African American adolescents, we tested the interactive effects of variation in the mu 1 opioid receptor (OPRM1) gene and the occurrence of stressful life events on symptoms of depression.

Method

Interactive effects of 24 OPRM1 simple nucleotide polymorphisms (SNP) and adolescent report of stressful life events on depression were tested using multilevel regressions. SNPs were dummy coded to test both additive and dominate forms of coding.

Results

Five OPRM1 SNPs showed significant evidence of interaction with stressful life events to alter depression risk (or symptoms) after adjusting for multiple testing and the correlated nature of the SNPs. Follow-up analyses showed significant differences based on OPRM1 genotype at bo

SUBMITTER: Swann G 

PROVIDER: S-EPMC4083691 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature