A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors.

ABSTRACT:

Object

Seizures are a potentially devastating complication of resection of brain tumors. Consequently, many neurosurgeons administer prophylactic antiepileptic drugs (AEDs) in the perioperative period. However, it is currently unclear whether perioperative AEDs should be routinely administered to patients with brain tumors who have never had a seizure. Therefore, the authors conducted a prospective, randomized trial examining the use of phenytoin for postoperative seizure prophylaxis in patients undergoing resection for supratentorial brain metastases or gliomas.

Methods

Patients with brain tumors (metastases or gliomas) who did not have seizures and who were undergoing craniotomy for tumor resection were randomized to receive either phenytoin for 7 days after tumor resectio

SUBMITTER: Wu AS 

PROVIDER: S-EPMC4083773 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature