Identification of gene ontologies linked to prefrontal-hippocampal functional coupling in the human brain.

ABSTRACT: Functional interactions between the dorsolateral prefrontal cortex and hippocampus during working memory have been studied extensively as an intermediate phenotype for schizophrenia. Coupling abnormalities have been found in patients, their unaffected siblings, and carriers of common genetic variants associated with schizophrenia, but the global genetic architecture of this imaging phenotype is unclear. To achieve genome-wide hypothesis-free identification of genes and pathways associated with prefrontal-hippocampal interactions, we combined gene set enrichment analysis with whole-genome genotyping and functional magnetic resonance imaging data from 269 healthy German volunteers. We found significant enrichment of the synapse organization and biogenesis gene set. This gene set included kno

SUBMITTER: Dixson L 

PROVIDER: S-EPMC4084419 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature