Dissociable contribution of prefrontal and striatal dopaminergic genes to learning in economic games.

ABSTRACT: Game theory describes strategic interactions where success of players' actions depends on those of coplayers. In humans, substantial progress has been made at the neural level in characterizing the dopaminergic and frontostriatal mechanisms mediating such behavior. Here we combined computational modeling of strategic learning with a pathway approach to characterize association of strategic behavior with variations in the dopamine pathway. Specifically, using gene-set analysis, we systematically examined contribution of different dopamine genes to variation in a multistrategy competitive game captured by (i) the degree players anticipate and respond to actions of others (belief learning) and (ii) the speed with which such adaptations take place (learning rate). We found that variation in ge

SUBMITTER: Set E 

PROVIDER: S-EPMC4084431 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature