Regulation of germinal center responses and B-cell memory by the chromatin modifier MOZ.

ABSTRACT: Memory B cells and long-lived bone marrow-resident plasma cells maintain humoral immunity. Little is known about the intrinsic mechanisms that are essential for forming memory B cells or endowing them with the ability to rapidly differentiate upon reexposure while maintaining the population over time. Histone modifications have been shown to regulate lymphocyte development, but their role in regulating differentiation and maintenance of B-cell subsets during an immune response is unclear. Using stage-specific deletion of monocytic leukemia zinc finger protein (MOZ), a histone acetyltransferase, we demonstrate that mutation of this chromatin modifier alters fate decisions in both primary and secondary responses. In the absence of MOZ, germinal center B cells were significantly impaired in t

SUBMITTER: Good-Jacobson KL 

PROVIDER: S-EPMC4084455 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature