Heart- and muscle-derived signaling system dependent on MED13 and Wingless controls obesity in Drosophila.

ABSTRACT: Obesity develops in response to an imbalance of energy homeostasis and whole-body metabolism. Muscle plays a central role in the control of energy homeostasis through consumption of energy and signaling to adipose tissue. We reported previously that MED13, a subunit of the Mediator complex, acts in the heart to control obesity in mice. To further explore the generality and mechanistic basis of this observation, we investigated the potential influence of MED13 expression in heart and muscle on the susceptibility of Drosophila to obesity. Here, we show that heart/muscle-specific knockdown of MED13 or MED12, another Mediator subunit, increases susceptibility to obesity in adult flies. To identify possible muscle-secreted obesity regulators, we performed an RNAi-based genetic screen of 150 gen

SUBMITTER: Lee JH 

PROVIDER: S-EPMC4084481 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature