Influence of surface topography on the human epithelial cell response to micropatterned substrates with convex and concave architectures.

ABSTRACT:

Background

Understanding the fundamental mechanisms underlying the cellular response to topographical surface features will extend our knowledge regarding the regulation of cell functions. Analyzing the cellular response to different topographical features, over multiple temporal and spatial scales, is central to understanding and guiding several biological functions. We used micropatterned substrates with convex and concave architectures to evaluate the behaviors of human epithelial cells on these substrates.

Results

Pillar and pit substrates caused heterogeneous spatial growth and distribution, with differences in cell density, over 48 h. Regional densities and distribution were significantly increased at pillar sidewalls, and at pit sidewalls and bottoms compared with tho

SUBMITTER: Kim MH 

PROVIDER: S-EPMC4084502 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature