A meta-analysis of lung cancer gene expression identifies PTK7 as a survival gene in lung adenocarcinoma.

ABSTRACT: Lung cancer remains the most common cause of cancer-related death worldwide and it continues to lack effective treatment. The increasingly large and diverse public databases of lung cancer gene expression constitute a rich source of candidate oncogenic drivers and therapeutic targets. To define novel targets for lung adenocarcinoma, we conducted a large-scale meta-analysis of genes specifically overexpressed in adenocarcinoma. We identified an 11-gene signature that was overexpressed consistently in adenocarcinoma specimens relative to normal lung tissue. Six genes in this signature were specifically overexpressed in adenocarcinoma relative to other subtypes of non-small cell lung cancer (NSCLC). Among these genes was the little studied protein tyrosine kinase PTK7. Immunohistochemical ana

SUBMITTER: Chen R 

PROVIDER: S-EPMC4084668 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature