Mixed-lineage kinase 3 deficiency promotes neointima formation through increased activation of the RhoA pathway in vascular smooth muscle cells.

ABSTRACT:

Objective

Mitogen-activated protein kinase pathways play an important role in neointima formation secondary to vascular injury, in part by promoting proliferation of vascular smooth muscle cells (VSMC). Mixed-lineage kinase 3 (MLK3) is a mitogen-activated protein kinase kinase kinase that activates multiple mitogen-activated protein kinase pathways and has been implicated in regulating proliferation in several cell types. However, the role of MLK3 in VSMC proliferation and neointima formation is unknown. The aim of this study was to determine the function of MLK3 in the development of neointimal hyperplasia and to elucidate the underlying mechanisms.

Approach and results

Neointima formation was analyzed after endothelial denudation of carotid arteries from wild-type and MLK3

SUBMITTER: Gadang V 

PROVIDER: S-EPMC4084683 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature