Deep dermatophytosis and inherited CARD9 deficiency.

ABSTRACT:

Background

Deep dermatophytosis is a severe and sometimes life-threatening fungal infection caused by dermatophytes. It is characterized by extensive dermal and subcutaneous tissue invasion and by frequent dissemination to the lymph nodes and, occasionally, the central nervous system. The condition is different from common superficial dermatophyte infection and has been reported in patients with no known immunodeficiency. Patients are mostly from North African, consanguineous, multiplex families, which strongly suggests a mendelian genetic cause.

Methods

We studied the clinical features of deep dermatophytosis in 17 patients with no known immunodeficiency from eight unrelated Tunisian, Algerian, and Moroccan families. Because CARD9 (caspase recruitment domain-containing prot

SUBMITTER: Lanternier F 

PROVIDER: S-EPMC4084693 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature