Refined ambient PM2.5 exposure surrogates and the risk of myocardial infarction.

ABSTRACT: Using a case-crossover study design and conditional logistic regression, we compared the relative odds of transmural (full-wall) myocardial infarction (MI) calculated using exposure surrogates that account for human activity patterns and the indoor transport of ambient PM(2.5) with those calculated using central-site PM(2.5) concentrations to estimate exposure to PM(2.5) of outdoor origin (exposure to ambient PM(2.5)). Because variability in human activity and indoor PM(2.5) transport contributes exposure error in epidemiologic analyses when central-site concentrations are used as exposure surrogates, we refer to surrogates that account for this variability as "refined" surrogates. As an alternative analysis, we evaluated whether the relative odds of transmural MI associated with increases

SUBMITTER: Hodas N 

PROVIDER: S-EPMC4084717 | biostudies-literature | 2013 Nov-Dec

REPOSITORIES: biostudies-literature