Membrane carbonic anhydrase IX expression and relapse risk in resected stage I-II non-small-cell lung cancer.

ABSTRACT:

Background

Adjuvant chemotherapy reduces recurrences of non-small-cell lung cancer (NSCLC). To determine which patients need adjuvant chemotherapy, we assessed factors associated with time to relapse (TTR).

Methods

In 230 resected stage I-II NSCLCs, we correlated immunohistochemistry scores for factors associated with cell growth rate, growth regulation, hypoxia, cell survival, and cell death with TTR.

Results

With a median follow-up of 82 months (1-158) for those alive and relapse free at last follow-up, median time to recurrence was not reached. The 2- and 5-year probabilities of maintaining freedom from recurrence were 80.7% (95% confidence interval, 75.3%, 86.4%) and 74.6% (95% confidence interval, 68.6%, 81.2%), respectively. TTR curves flattened at an apparent c

SUBMITTER: Stewart DJ 

PROVIDER: S-EPMC4084898 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature