Construction of a versatile and functional nanoparticle platform derived from a helical diblock copolypeptide-based biomimetic polymer.

ABSTRACT: Sequential polymerization of N-carboxyanhydrides accelerated by nitrogen flow is utilized to generate a novel well-defined diblock copolypeptide (PDI = 1.08), with incorporation of alkyne-functionalized side-chain groups allowing for rapid and efficient thiol-yne click-type modifications, followed by self-assembly into nanopure water to construct a helical polypeptide-based versatile and functional nanoparticle platform.

SUBMITTER: Fan J 

PROVIDER: S-EPMC4084918 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature