Effect of hypnotherapy and educational intervention on brain response to visceral stimulus in the irritable bowel syndrome.

ABSTRACT:

Background

Gut-directed hypnotherapy can reduce IBS symptoms, but the mechanisms underlying this therapeutic effect remain unknown.

Aim

To determine the effect of hypnotherapy and educational intervention on brain responses to cued rectal distensions in IBS patients.

Methods

Forty-four women with moderate-to-severe IBS and 20 healthy controls (HCs) were included. Blood oxygen level dependent (BOLD) signals were measured by functional Magnetic Resonance Imaging (fMRI) during expectation and delivery of high- (45 mmHg) and low-intensity (15 mmHg) rectal distensions. Twenty-five patients were assigned to hypnotherapy (HYP) and 16 to educational intervention (EDU). Thirty-one patients completed treatments and posttreatment fMRI.

Results

Similar symptom reduction wa

SUBMITTER: Lowen MB 

PROVIDER: S-EPMC4084976 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature