Mathematical and live meningococcal models for simple sequence repeat dynamics - coherent predictions and observations.

ABSTRACT: Evolvability by means of simple sequence repeat (SSR) instability is a feature under the constant influence of opposing selective pressures to expand and compress the repeat tract and is mechanistically influenced by factors that affect genetic instability. In addition to direct selection for protein expression and structural integrity, other factors that influence tract length evolution were studied. The genetic instability of SSRs that switch the expression of antibiotic resistance ON and OFF was modelled mathematically and monitored in a panel of live meningococcal strains. The mathematical model showed that the SSR length of a theoretical locus in an evolving population may be shaped by direct selection of expression status (ON or OFF), tract length dependent (α) and tract length indep

SUBMITTER: Alfsnes K 

PROVIDER: S-EPMC4085013 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature