Nanometer scale titanium surface texturing are detected by signaling pathways involving transient FAK and Src activations.

ABSTRACT:

Background

It is known that physico/chemical alterations on biomaterial surfaces have the capability to modulate cellular behavior, affecting early tissue repair. Such surface modifications are aimed to improve early healing response and, clinically, offer the possibility to shorten the time from implant placement to functional loading. Since FAK and Src are intracellular proteins able to predict the quality of osteoblast adhesion, this study evaluated the osteoblast behavior in response to nanometer scale titanium surface texturing by monitoring FAK and Src phosphorylations.

Methodology

Four engineered titanium surfaces were used for the study: machined (M), dual acid-etched (DAA), resorbable media microblasted and acid-etched (MBAA), and acid-etch microblasted (AAMB). Surf

SUBMITTER: Zambuzzi WF 

PROVIDER: S-EPMC4085036 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature