Intraindividual variability of C-reactive protein: the Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Background

The intraindividual variability of C-reactive protein (CRP) remains uncertain. Although guidelines suggest stability of serial CRP values comparable to that of cholesterol measures, several studies indicate greater fluctuations of CRP. We sought to compare the intraindividual variability of CRP with that of cholesterol measures using the multi-ethnic study of atherosclerosis (MESA).

Methods

CRP measurements were available in 760 MESA participants after exclusion of those with comorbidities or medications known to affect CRP or CRP≥10 mg/L. Serial values were available for 255 participants. The intraclass correlation coefficient (ICC) was quantified for CRP, total cholesterol (TC), and non-HDL-cholesterol (non-HDL-C) as the ratio of between-subject variance to the

SUBMITTER: DeGoma EM 

PROVIDER: S-EPMC4085141 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature