Serum inflammatory markers and risk of colorectal cancer in patients with inflammatory bowel diseases.

ABSTRACT:

Background & aims

Patients with inflammatory bowel diseases (IBDs) (Crohn's disease, ulcerative colitis) are at increased risk of colorectal cancer (CRC). Persistent inflammation is hypothesized to increase risk of CRC in patients with IBD; however, the few studies in this area have been restricted to cross-sectional assessments of histologic severity. No prior studies have examined association between C-reactive protein (CRP) or erythrocyte sedimentation rate (ESR) elevation and risk of CRC in an IBD cohort.

Methods

From a multi-institutional validated IBD cohort, we identified all patients with at least one measured CRP or ESR value. Patients were stratified into quartiles of severity of inflammation on the basis of their median CRP or ESR value, and subsequent diagnosis o

SUBMITTER: Ananthakrishnan AN 

PROVIDER: S-EPMC4085150 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature