Intrinsic hippocampal activity as a biomarker for cognition and symptoms in schizophrenia.

ABSTRACT:

Objective

Identification of biomarkers for cognitive dysfunction in schizophrenia is a priority for psychiatry research. Functional imaging studies suggest that intrinsic "resting state" hippocampal hyperactivity is a characteristic feature of schizophrenia. The relationships between this phenotype and symptoms of the illness, however, are largely unexplored. The authors examined resting hippocampal activity in schizophrenia patients and healthy comparison subjects and analyzed the relationship between intrinsic hippocampal activity and cognitive function in patients as measured by the MATRICS Consensus Cognitive Battery (MCCB).

Method

Twenty-eight schizophrenia patients and 28 age-matched healthy comparison subjects underwent functional "resting state" 3-T MR scanning. Hipp

SUBMITTER: Tregellas JR 

PROVIDER: S-EPMC4085164 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature