Nuclear repulsion enables division autonomy in a single cytoplasm.

ABSTRACT:

Background

Current models of cell-cycle control, based on classic studies of fused cells, predict that nuclei in a shared cytoplasm respond to the same CDK activities to undergo synchronous cycling. However, synchrony is rarely observed in naturally occurring syncytia, such as the multinucleate fungus Ashbya gossypii. In this system, nuclei divide asynchronously, raising the question of how nuclear timing differences are maintained despite sharing a common milieu.

Results

We observe that neighboring nuclei are highly variable in division-cycle duration and that neighbors repel one another to space apart and demarcate their own cytoplasmic territories. The size of these territories increases as a nucleus approaches mitosis and can influence cycling rates. This nonrandom nucle

SUBMITTER: Anderson CA 

PROVIDER: S-EPMC4085259 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature