Estrogen receptor α gene polymorphisms and risk of Alzheimer's disease: evidence from a meta-analysis.

ABSTRACT:

Objective

Human estrogen receptor α (ESR1), a member of the nuclear receptor superfamily of ligand-activated transcription factors, is one of the key mediators of hormonal response in estrogen-sensitive tissues. Accumulating evidence has demonstrated that two of the most widely studied single-nucleotide polymorphisms in ESR1 - PvuII (T/C, rs223493) and Xbal (A/G, rs9340799) - are possibly associated with Alzheimer's disease (AD). However, individual study results are still controversial.

Materials and methods

We searched PubMed, Embase, Web of Science, Science Direct, SpringerLink, and the Chinese National Knowledge Infrastructure databases for eligible studies assessing the association of ESR1 polymorphisms and AD risk (last search performed in November 2013). Thereafter, a

SUBMITTER: Cheng D 

PROVIDER: S-EPMC4085310 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature