Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change.

ABSTRACT: Multiple cancers may arise from within a clonal region of preneoplastic epithelium, a phenomenon termed 'field change'. However, it is not known how field change develops. Here we investigate this question using lineage tracing to track the behaviour of scattered single oesophageal epithelial progenitor cells expressing a mutation that inhibits the Notch signalling pathway. Notch is frequently subject to inactivating mutation in squamous cancers. Quantitative analysis reveals that cell divisions that produce two differentiated daughters are absent from mutant progenitors. As a result, mutant clones are no longer lost by differentiation and become functionally immortal. Furthermore, mutant cells promote the differentiation of neighbouring wild-type cells, which are then lost from the tissue

SUBMITTER: Alcolea MP 

PROVIDER: S-EPMC4085550 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature