A genetic variant in pseudogene E2F3P1 contributes to prognosis of hepatocellular carcinoma.

ABSTRACT: Certain pseudogenes may regulate their protein-coding cousins by competing for miRNAs and play an active biological role in cancer. However, few studies have focused on the association of genetic variations in pseudogenes with cancer prognosis. We selected six potentially functional single nucleotide polymorphisms (SNPs) in cancer-related pseudogenes, and performed a case-only study to assess the association between those SNPs and the prognosis of hepatocellular carcinoma (HCC) in 331 HBV-positive HCC patients without surgical treatment. Log-rank test and Cox proportional hazard models were used for survival analysis. We found that the A allele of rs9909601 in E2F3P1 was significantly associated with a better prognosis compared with the G allele [adjusted hazard ratio (HR)  =  0.69, 95% co

SUBMITTER: Pan Y 

PROVIDER: S-EPMC4085556 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature