Convergent cortical innervation of striatal projection neurons.

ABSTRACT: Anatomical studies have led to the assertion that intratelencephalic and pyramidal tract cortical neurons innervate different striatal projection neurons. To test this hypothesis, we measured the responses of mouse striatal neurons to optogenetic activation of intratelencephalic and pyramidal tract axons. Contrary to expectation, direct and indirect pathway striatal spiny projection neurons responded to both intratelencephalic and pyramidal tract activation, arguing that these cortical networks innervate both striatal projection neurons.

SUBMITTER: Kress GJ 

PROVIDER: S-EPMC4085670 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature