Cord blood mesenchymal stem cells suppress DC-T Cell proliferation via prostaglandin B2.

ABSTRACT: Immune suppression is a very stable property of multipotent stromal cells also known as mesenchymal stem cells (MSCs). All cell lines tested showed robust immune suppression not affected by a long culture history. Several mechanisms were described to account for this capability. Since several of the described mechanisms were not causing the immune suppression, the expression pattern of cord-blood-derived MSCs by microarray experiments was determined. Dendritic cells cocultured with cord blood MSCs were compared with cord blood MSCs. Putative immune suppressive candidates were tested to explain this inhibition. We find that cord blood MSCs themselves are hardly immunogenic as tested with allogeneic T-cells. Dendritic cells cocultured with second-party T-cells evoked abundant proliferation t

SUBMITTER: van den Berk LC 

PROVIDER: S-EPMC4085994 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature