COUGER--co-factors associated with uniquely-bound genomic regions.

ABSTRACT: Most transcription factors (TFs) belong to protein families that share a common DNA binding domain and have very similar DNA binding preferences. However, many paralogous TFs (i.e. members of the same TF family) perform different regulatory functions and interact with different genomic regions in the cell. A potential mechanism for achieving this differential in vivo specificity is through interactions with protein co-factors. Computational tools for studying the genomic binding profiles of paralogous TFs and identifying their putative co-factors are currently lacking. Here, we present an interactive web implementation of COUGER, a classification-based framework for identifying protein co-factors that might provide specificity to paralogous TFs. COUGER takes as input two sets of genomic re

SUBMITTER: Munteanu A 

PROVIDER: S-EPMC4086139 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature