Treatment-resistant depression in primary care across Canada.

ABSTRACT:

Objective

Treatment-resistant depression (TRD) represents a considerable global health concern. The goal of the InSight study was to investigate the prevalence of TRD and to evaluate its clinical characterization and management, compared with nonresistant depression, in primary care centres.

Methods

Physicians completed a case report on a consecutive series of patients with major depressive disorder (n = 1212), which captured patient demographics and comorbidity, as well as current and past medication.

Results

Using failure to respond to at least 2 antidepressants (ADs) from different classes as the definition of TRD, the overall prevalence was 21.7%. There were no differences in prevalence between men and women or among ethnicities. Patients with TRD had longer episo

SUBMITTER: Rizvi SJ 

PROVIDER: S-EPMC4086317 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature