Activation of multiple transcriptional regulators by growth restriction in Pseudomonas aeruginosa.

ABSTRACT: Growth restriction by antibiotics is a common feature that pathogenic bacteria must overcome for survival. The struggle of bacteria to escape from growth restriction eventually results in development of antibiotic-resistance through the expression of a set of genes. Here we found that some physiologically important transcriptional regulators of Pseudomonas aeruginosa including QscR, a quorum sensing (QS) receptor, SoxR, a superoxide sensor-regulator, and AntR, a regulator of anthranilate-related secondary metabolism, are activated by various growth-restricted conditions. We generated the growth-restricted conditions by various methods, such as overexpression of PA2537 and treatment with antibiotics or disinfectants. The overexpression of PA2537, encoding an acyltransferase homologue, tight

SUBMITTER: Yeom DH 

PROVIDER: S-EPMC4086342 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature