Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions.

ABSTRACT: About 25% of high-grade cervical intraepithelial neoplasias (CIN2/3) caused by human papillomavirus serotype 16 (HPV16) undergo complete spontaneous regression. However, to date, therapeutic vaccination strategies for HPV disease have yielded limited success when measured by their ability to induce robust peripheral blood T cell responses to vaccine antigen. We report marked immunologic changes in the target lesion microenvironment after intramuscular therapeutic vaccination targeting HPV16 E6/E7 antigens, in subjects with CIN2/3 who had modest detectable responses in circulating T lymphocytes. Histologic and molecular changes, including markedly (average threefold) increased intensity of CD8(+) T cell infiltrates in both the stromal and epithelial compartments, suggest an effector respons

SUBMITTER: Maldonado L 

PROVIDER: S-EPMC4086631 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature