A genome-scale metabolic flux model of Escherichia coli K-12 derived from the EcoCyc database.

ABSTRACT:

Background

Constraint-based models of Escherichia coli metabolic flux have played a key role in computational studies of cellular metabolism at the genome scale. We sought to develop a next-generation constraint-based E. coli model that achieved improved phenotypic prediction accuracy while being frequently updated and easy to use. We also sought to compare model predictions with experimental data to highlight open questions in E. coli biology.

Results

We present EcoCyc-18.0-GEM, a genome-scale model of the E. coli K-12 MG1655 metabolic network. The model is automatically generated from the current state of EcoCyc using the MetaFlux software, enabling the release of multiple model updates per year. EcoCyc-18.0-GEM encompasses 1445 genes, 2286 unique metabolic reactions, and

SUBMITTER: Weaver DS 

PROVIDER: S-EPMC4086706 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature