Gastroesophageal reflux disease symptom severity, proton pump inhibitor use, and esophageal carcinogenesis.

ABSTRACT:

Hypothesis

Screening for esophageal adenocarcinoma has focused on identifying Barrett esophagus (BE) in patients with severe, long-standing symptoms of gastroesophageal reflux disease (GERD). Unfortunately, 95% of patients who develop esophageal adenocarcinoma are unaware of the presence of BE before their cancer diagnosis, which means they never had been selected for screening. One possible explanation is that no correlation exists between the severity of GERD symptoms and cancer risk. We hypothesize that severe GERD symptoms are not associated with an increase in the prevalence of BE, dysplasia, or cancer in patients undergoing primary endoscopic screening.

Design

Cross-sectional study.

Setting

University hospital.

Patients

A total of 769 patients with GERD.<

SUBMITTER: Nason KS 

PROVIDER: S-EPMC4086744 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature