RhBSSL improves growth and LCPUFA absorption in preterm infants fed formula or pasteurized breast milk.

ABSTRACT:

Objectives

Preterm infants often experience suboptimal growth, which can affect organ development. The aim of this study was to improve growth by treatment with bile salt-stimulated lipase (BSSL), naturally present in breast milk, but lost after pasteurization, and absent in formula.

Methods

Two clinical trials were performed with a predefined analysis of combined data to investigate the effects of recombinant human BSSL (rhBSSL) treatment on growth velocity and fat absorption in preterm infants. The studies were randomized and double-blinded comparing 7-day treatment with rhBSSL and placebo, administered in pasteurized breast milk or formula, using a crossover design.

Results

Sixty-three infants were evaluated for safety. At randomization, the mean (standard deviatio

SUBMITTER: Casper C 

PROVIDER: S-EPMC4086776 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature