The risk of congenital malformations associated with exposure to β-blockers early in pregnancy: a meta-analysis.

ABSTRACT: β-blockers are commonly used during the first trimester of pregnancy. Data about risks of congenital anomalies in offspring have not been summarized. We performed a meta-analysis to determine teratogenicity of β-blockers in early pregnancy. A systematic literature search was performed using PubMed, EMBASE, Cochrane Clinical Trials, and hand search. Meta-analyses were performed using random-effects models based on odds ratios (ORs). Prespecified subgroup analyses were performed to explore heterogeneity. Randomized controlled trials or observational studies examining risks of congenital malformations associated with first trimester β-blocker exposure compared with no exposure were included. Thirteen population-based case-control or cohort studies were identified. Based on meta-analyses, firs

SUBMITTER: Yakoob MY 

PROVIDER: S-EPMC4086784 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature