Isoniazid, pyrazinamide and rifampicin content variation in split fixed-dose combination tablets.

ABSTRACT:

Setting

In most developing countries, paediatric tuberculosis is treated with split tablets leading to potential inaccuracy in the dose delivery and drug exposure. There is no data on the quality of first-line drugs content in split fixed-dose combination tablets.

Objective

To determine Isoniazid, Pyrazinamide and Rifampicin content uniformity in split FDC tablets used in the treatment of childhood tuberculosis.

Design

Drug contents of 15 whole tablets, 30 half tablets and 36 third tablets were analysed by high performance liquid chromatography. The content uniformity was assessed by comparing drug content measured in split portions with their expected amounts and the quality of split portions was assessed applying qualitative specifications for whole tablets.

Resu

SUBMITTER: Pouplin T 

PROVIDER: S-EPMC4086978 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature