MiR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment.

ABSTRACT: Major depressive disorder (MDD) is a prevalent mood disorder that is associated with differential prefrontal brain expression patterns. Treatment of MDD includes a variety of biopsychosocial approaches. In medical practice, antidepressant drugs are the most common treatment for depressive episodes, and they are among the most prescribed medications in North America. Although antidepressants are clearly effective, particularly for moderate to severe depressive episodes, there is variability in how individuals respond to antidepressant treatment. Failure to respond has individual, economic and social consequences for patients and their families. Several lines of evidence demonstrate that genes are regulated through the activity of microRNAs (miRNAs), which act as fine-tuners and on-off switc

SUBMITTER: Lopez JP 

PROVIDER: S-EPMC4087015 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature