Acetaminophen attenuates lipid peroxidation in children undergoing cardiopulmonary bypass.

ABSTRACT:

Objective

Hemolysis, occurring during cardiopulmonary bypass, is associated with lipid peroxidation and postoperative acute kidney injury. Acetaminophen inhibits lipid peroxidation catalyzed by hemeproteins and in an animal model attenuated rhabdomyolysis-induced acute kidney injury. This pilot study tests the hypothesis that acetaminophen attenuates lipid peroxidation in children undergoing cardiopulmonary bypass.

Design

Single-center prospective randomized double-blinded study.

Setting

University-affiliated pediatric hospital.

Patients

Thirty children undergoing elective surgical correction of a congenital heart defect.

Interventions

Patients were randomized to acetaminophen (OFIRMEV [acetaminophen] injection; Cadence Pharmaceuticals, San Diego, CA) or

SUBMITTER: Simpson SA 

PROVIDER: S-EPMC4087071 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature