Combining NSE and S100B with clinical examination findings to predict survival after resuscitation from cardiac arrest.

ABSTRACT:

Background

Neuron specific enolase (NSE) and astroglial protein S100B are associated with outcome following resuscitation from cardiac arrest. We tested whether NSE and S100B levels are associated with illness severity on hospital arrival, and whether levels are independently associated with survival to hospital discharge after adjusting for initial illness severity.

Methods

Levels of NSE and S100B were obtained at arrival, 6, 12, 24, 48, and 72h after successful resuscitation from cardiac arrest. Clinical data included demographics, Pittsburgh Cardiac Arrest Category (PCAC I-IV) and survival to hospital discharge. Univariable and multivariable predictive models including NSE and S-100B were created to predict survival. ROC analyses were performed to determine sensitivity an

SUBMITTER: Calderon LM 

PROVIDER: S-EPMC4087150 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature