Defensin expression in chronic pouchitis in patients with ulcerative colitis or familial adenomatous polyposis coli.

ABSTRACT:

Aim

Pouchitis develops in ileoanal pouches in up to 50% of patients with ulcerative colitis during the first 10 years after pouch surgery while being rare in patients after proctocolectomy for familial adenomatous polyposis coli (FAP) syndrome. Defensins are major components of the innate immune system and play a significant role in gastrointestinal microbial homeostasis. Pouch defensin and cytokine expression were correlated with states of pouch inflammation to study their role in pouchitis.

Methods

Patients with ulcerative colitis and FAP syndrome were stratified into groups with pouches after surgery, pouches without or with pouchitis. Biopsies from terminal ileum from a healthy intestine or from normal terminal ileum of patients with ulcerative colitis served as controls

SUBMITTER: Kiehne K 

PROVIDER: S-EPMC4087897 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature