Significance of serum IgA in patients with acute hepatitis E virus infection.

ABSTRACT:

Aim

To study the significance of serum anti-hepatitis E virus (HEV) IgA in patients with hepatitis E.

Methods

A new method was established to assay anti-HEV IgA, which could be detected in the middle phase of the infection. We compared anti-HEV IgA assay with anti-HEV IgM and anti-HEV IgG assay in sera from 60 patients with positive HEV-RNA.

Results

The 60 patients with positive HEV-RNA had both anti-HEV IgA and anti-HEV IgM and 410 patients with negative HEV-RNA were used as control. Periodic serum samples obtained from 60 patients with hepatitis E were tested for HEV RNA, anti-HEV IgM, anti-HEV IgA and anti-HEV IgG. Their HEV-RNA was detectable in the serum until 20 +/- 11 d. We used anti-HEV IgM and anti-HEV IgA assay to detect HEV infection and positive results we

SUBMITTER: Tian DY 

PROVIDER: S-EPMC4087946 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature