Height, adiposity and hormonal cardiovascular risk markers in childhood: how to partition the associations?

ABSTRACT:

Objective

Obesity is associated with rapid growth during childhood. There is uncertainty over how to adjust for body size, when using adiposity as a proxy for cardiovascular risk. We studied associations of height, body composition (by dual-energy X-ray absorptiometry) and cardiovascular risk markers (insulin resistance (IR), leptin) in children.

Methods

Using partial correlations in 172 children aged 7-12 years, we investigated associations of (a) fat mass with IR or leptin, adjusting for height or lean mass, and (b) height or lean mass with IR or leptin, adjusting for fat mass. Analyses were conducted both cross-sectionally at each age, and for changes between 7 and 12 years.

Results

Height, fat mass, lean mass, IR and leptin were all inter-correlated at all ages. A

SUBMITTER: Wells JC 

PROVIDER: S-EPMC4088335 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature