Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery.

ABSTRACT:

Background

We have recently shown by formally modelling human protein interaction networks (PINs) as metric spaces and classified proteins into zones based on their distance from the topological centre that hub proteins are primarily centrally located. We also showed that zones closest to the network centre are enriched for critically important proteins and are also functionally very specialised for specific 'house keeping' functions. We proposed that proteins closest to the network centre may present good therapeutic targets. Here, we present multiple pieces of novel functional evidence that provides strong support for this hypothesis.

Results

We found that the human PINs has a highly connected signalling core, with the majority of proteins involved in signalling located in

SUBMITTER: Fadhal E 

PROVIDER: S-EPMC4088370 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature