Crystallization and preliminary X-ray analysis of RabX3, a tandem GTPase from Entamoeba histolytica.

ABSTRACT: Ras superfamily GTPases regulate signalling pathways that control multiple biological processes by modulating the GTP/GDP cycle. Various Rab GTPases, which are the key regulators of vesicular trafficking pathways, play a vital role in the survival and virulence of the enteric parasite Entamoeba histolytica. The Rab GTPases act as binary molecular switches that utilize the conformational changes associated with the GTP/GDP cycle to elicit responses from target proteins and thereby regulate a broad spectrum of cellular processes including cell proliferation, cytoskeletal assembly, nuclear transport and intracellular membrane trafficking in eukaryotes. Entamoeba histolytica RabX3 (EhRabX3) is a unique GTPase in the amoebic genome, the only member in the eukaryotic Ras superfamily that harbour

SUBMITTER: Kumar Srivastava V 

PROVIDER: S-EPMC4089535 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature