DNA methylation of the LY86 gene is associated with obesity, insulin resistance, and inflammation.

ABSTRACT:

Background

Previous genome-wide association studies (GWAS) have identified a large number of genetic variants for obesity and its related traits, representing a group of potential key genes in the etiology of obesity. Emerging evidence suggests that epigenetics may play an important role in obesity. It has not been explored whether the GWAS-identified loci contribute to obesity through epigenetics (e.g., DNA (deoxyribonucleic acid) methylation) in addition to genetics.

Method

A multi-stage cross-sectional study was designed. We did a literature search and identified 117 genes discovered by GWAS for obesity and its related traits. Then we analyzed whether the methylation levels of these genes were also associated with obesity in two genome-wide methylation panels. We examined

SUBMITTER: Su S 

PROVIDER: S-EPMC4090018 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature