Ontology highlight
ABSTRACT:
SUBMITTER: Hall JA
PROVIDER: S-EPMC4090037 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Hall Jessica A JA Kusuma Bhaskar Reddy BR Brandt Gary E L GE Blagg Brian S J BS
ACS chemical biology 20140212 4
The molecular chaperone Hsp90 requires the assistance of immunophilins, co-chaperones, and partner proteins for the conformational maturation of client proteins. Hsp90 inhibition represents a promising anticancer strategy due to the dependence of numerous oncogenic signaling pathways upon Hsp90 function. Historically, small molecules have been designed to inhibit ATPase activity at the Hsp90 N-terminus; however, these molecules also induce the pro-survival heat shock response (HSR). Therefore, i ...[more]