Acute pyelonephritis in renal allografts: a new role for microRNAs?

ABSTRACT:

Background

Acute pyelonephritis (APN) versus acute rejection (AR) is a frequently encountered diagnostic and therapeutic dilemma in kidney transplants. Variable culture results, overlapping histologic features, and persistent graft dysfunction despite antibiotics are frequently encountered. Therefore, we explored the utility of intragraft microRNA profiles to distinguish between allograft APN and AR.

Materials and methods

Between 2003 and 2011, we identified 49 patients with biopsy features of APN, within the first 2 years posttransplant. MicroRNA profiling was performed on 20 biopsies (normal kidney, n=4; unequivocal AR, n=5; features of APN, n=11).

Results

Only 32% (16/49) of the patients had concomitant positive urine cultures at biopsy, and in 8 of 16 patients, co

SUBMITTER: Oghumu S 

PROVIDER: S-EPMC4090250 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature