Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is a severe chronic immune mediated inflammatory disease that has been shown to be associated with human leukocyte antigen (HLA) loci. The transporter associated with antigen processing 2 (TAP2) has been identified to play an important role in the HLA-associated diseases and immune response. The goal of our meta-analysis was to summarize the contribution of TAP2 polymorphisms to the risk of RA.

Methods

Meta-analyses were performed between RA and 3 TAP2 coding polymorphisms that comprised TAP2-379Ile > Val (rs1800454), TAP2-565Ala > Thr (rs2228396) and TAP2-665Thr > Ala (rs241447). The meta-analyses were involved with 9 studies (24 individual studies) among 973 cases and 965 controls.

Results

Meta-analyses showed that TAP2-379Ile al

SUBMITTER: Dai D 

PROVIDER: S-EPMC4090395 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature