Dataset Information

Rationale, design and baseline results of the Guangxi manganese-exposed workers healthy cohort (GXMEWHC) study.

ABSTRACT:

Objective

To determine the relationship between biomarkers of exposure, disease and susceptibility, and early health effects and long-term diseases related to occupational manganese (Mn) exposure.

Design

Baseline survey of a longitudinal cohort study of workers in a ferromanganese refinery.

Participants

A total of 1888 individuals (1197 men, 691 women; average seniority 15.34 years) were enrolled in the Guangxi manganese-exposed workers healthy cohort (GXMEWHC) study. Participants were between 18 and 60 years of age (mean 40.31 years), had worked in the ferromanganese refinery for at least 1 year and lived in the local area.

Results

The GXMEWHC study included a baseline survey. Participants were divided into four groups according to manganese (Mn) cumulative exposure index (Mn-CEI) levels: an internal control group (Mn-CEI <1.0 mg/m(3) year), a low exposure group (1.0 mg/m(3) year≤Mn-CEI<2.0 mg/m(3) year), a medium exposure group (2.0 mg/m(3) year≤Mn-CEI<5.0 mg/m(3) year) and a high exposure group (Mn-CEI≥5.0 mg/m(3) year). Genome-wide association studies of quantitative trait loci and binary trait loci in 500 Mn-exposed workers were performed using Illumina Infinium HumanExome BeadChip arrays. Stored plasma, DNA, hair and urine are available for further study. Participants will be followed up every 3 years.

Conclusions

The GXMEWHC study provides abundant data for exploring the systemic health effects of occupational Mn exposure using biomarkers of exposure, disease and susceptibility.

SUBMITTER: Lv Y

PROVIDER: S-EPMC4091505 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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Publications

Rationale, design and baseline results of the Guangxi manganese-exposed workers healthy cohort (GXMEWHC) study.

Lv Yingnan Y Zou Yunfeng Y Liu Jing J Chen Kangcheng K Huang Damin D Shen Yuefei Y Zhong Yaoqiu Y Liu Zhihao Z Jiang Bei B Li Qin Q Qing Li L Zhang Wei W Chen Lang L Wang Fenfen F Xia Bing B Yang Li L Yang Xiaobo X

BMJ open 20140703 7

<h4>Objective</h4>To determine the relationship between biomarkers of exposure, disease and susceptibility, and early health effects and long-term diseases related to occupational manganese (Mn) exposure.<h4>Design</h4>Baseline survey of a longitudinal cohort study of workers in a ferromanganese refinery.<h4>Participants</h4>A total of 1888 individuals (1197 men, 691 women; average seniority 15.34 years) were enrolled in the Guangxi manganese-exposed workers healthy cohort (GXMEWHC) study. Parti ...[more]

PMID: 24993760

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Dataset Information

Rationale, design and baseline results of the Guangxi manganese-exposed workers healthy cohort (GXMEWHC) study.

Objective

Design

Participants

Results

Conclusions

Publications

Rationale, design and baseline results of the Guangxi manganese-exposed workers healthy cohort (GXMEWHC) study.

Similar Datasets

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