Risk of pancreatic cancer in families with Lynch syndrome.

ABSTRACT:

Context

Lynch syndrome is an inherited cause of colorectal cancer caused by mutations of DNA mismatch repair (MMR) genes. A number of extracolonic tumors have been associated with the disorder, including pancreatic cancer; however, the risk of pancreatic cancer in Lynch syndrome is uncertain and not quantified.

Objective

To estimate pancreatic cancer risk in families with germline MMR gene mutations.

Design, setting, and patients

Cancer histories of probands and their relatives were evaluated in MMR gene mutation carriers in the familial cancer registries of the Dana-Farber Cancer Institute (n = 80), Boston, Massachusetts, and University of Michigan Comprehensive Cancer Center (n = 67), Ann Arbor, Michigan. Families enrolled before the study start date (June 2008) wer

SUBMITTER: Kastrinos F 

PROVIDER: S-EPMC4091624 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature